From Seattle: (3 options)

I-5 North to Burlington
Hwy 20 East (North Cascade Scenic Highway * ) to Winthrop

I-90 East to Cle Elum
Hwy 970 East to Hwy 97 North
Hwy 2 East (& 97 North) to Wenatchee
Continue on Hwy 97 North to Pateros
Hwy 153 North to Twisp
Hwy 20 West to Winthrop

I-5 North to Everett
Hwy 2 East to Wenatchee
Hwy 97 North to Pateros
Hwy 153 North to Twisp
Hwy 20 West to Winthrop

From Spokane:

Hwy 2 West to Wilbur
Hwy 174 West (Grand Coulee & Chief Joseph Dams) to Bridgeport
Hwy 17 North to Hwy 97 South to Pateros
Hwy 153 North to Twisp
Hwy 20 West to Winthrop

*NOTE During the winter months (usually mid-November through mid-April) the North Cascade Highway 20 is closed. Call 1 800 695 ROAD, 511 or visit www.wsdot.wa.gov/traffic/passes for current conditions on all Washington State Mountain Passes.